Synonyms: Cytosolic methionine S sulfoxide reductase ,Methionine sulphoxide reductase A,Mitochondrial peptide methionine sulfoxide reductase,MSR A,msrA,MSRA,peptide met (O) reductase,Peptide Met(O) reductase,Peptide methionine (S) S oxide reductase,Peptide-methionine (S)-S-oxide reductase,PMSR,Protein methionine S oxide reductase,Protein-methionine-S-oxide reductase
Background: This gene encodes a ubiquitous and highly conserved protein that carries out the enzymatic reduction of methionine sulfoxide to methionine. Human and animal studies have shown the highest levels of expression in kidney and nervous tissue. The protein functions in the repair of oxidatively damaged proteins to restore biological activity. Alternative splicing results in multiple transcript variants.