Synonyms: BA46,Breast epithelial antigen BA46,EDIL1,HMFG,hP47,HsT19888,Lactadherin,Medin,MFG-E8,MFGE8,MFGM,MFGM,Milk fat globule EGF factor 8,Milk fat globule EGF factor 8 protein,Milk fat globule-EGF factor 8,O acetyl disialoganglioside synthase,OAcGD3S,SED1,SPAG10,Sperm associated antigen 10,Sperm surface protein hP47
Background: This gene encodes a preproprotein that is proteolytically processed to form multiple protein products. The major encoded protein product, lactadherin, is a membrane glycoprotein that promotes phagocytosis of apoptotic cells. This protein has also been implicated in wound healing, autoimmune disease, and cancer. Lactadherin can be further processed to form a smaller cleavage product, medin, which comprises the major protein component of aortic medial amyloid (AMA). Alternative splicing results in multiple transcript variants.