Synonyms: AFAR,AFAR1,AFB1 aldehyde reductase 1,AFB1 AR1,AFB1-AR 1,AFB1AR1,Aflatoxin aldehyde reductase,Aflatoxin B1 aldehyde reductase member 2,Aflatoxin beta1 aldehyde reductase,Aiar,AKR7,Akr7a2,Aldo keto reductase family 7,Aldo keto reductase family 7 member A2 aflatoxin aldehyde reductase,Aldo keto reductase family 7 member A2,Aldo keto reductase family 7,member A2 (aflatoxin aldehyde reductase),Aldoketoreductase 7,ARK72,SSA reductase,Succinic semialdehyde reductase
Background: The protein encoded by this gene belongs to the aldo/keto reductase (AKR) superfamily and AKR7 family, which are involved in the detoxification of aldehydes and ketones. The AKR7 family consists of 3 genes that are present in a cluster on the p arm of chromosome 1. This protein, thought to be localized in the golgi, catalyzes the NADPH-dependent reduction of succinic semialdehyde to the endogenous neuromodulator, gamma-hydroxybutyrate. It may also function as a detoxication enzyme in the reduction of aflatoxin B1 and 2-carboxybenzaldehyde. Alternative splicing results in multiple transcript variants.