Synonyms: 1200007E24Rik,ADP ribosylation factor binding protein 2,ADP ribosylation factor binding protein GGA 2,ADP ribosylation factor binding protein GGA2,ADP-ribosylation factor-binding protein GGA2,ARF-binding protein 2,FLJ20966,Gamma adaptin related protein 2,gamma ear-containing,Gamma-adaptin-related protein 2,GGA 2,Gga2,GGA2,Golgi associated gamma adaptin ear containing ARF binding protein 2,Golgi localized gamma ear containing ARF binding protein 2,Golgi-localized,KIAA1080,Vear,VHS domain and ear domain containing protein,VHS domain and ear domain of gamma adaptin,VHS domain and ear domain of gamma-adaptin
Background: This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) family. This family includes ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. This family member may play a significant role in cargo molecules regulation and clathrin-coated vesicle assembly.