Synonyms: AMPA 3,AMPA selective glutamate receptor 3,AMPA-selective glutamate receptor 3,dJ1171F9.1,GluA3,GLUK3,GluR 3,GLUR C,GLUR K3,GluR-3,GluR-C,GluR-K3,GLUR3,GLURC,Glutamate ionotropic receptor AMPA type subunit 3,Glutamate receptor 3,Glutamate receptor C,Glutamate receptor ionotrophic AMPA 3,Glutamate receptor ionotropic,Glutamate receptor subunit 3,Glutamate receptor,ionotropic,AMPA 3,GRIA 3,Gria3,GRIA3,Ionotrophic Glutamate Receptor,MRX94
Background: Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA, R->G). Alternative splicing at this locus results in different isoforms, which may vary in their signal transduction properties.