Synonyms: Bromodomain and WD repeat containing protein 2,Bromodomain and WD repeat domain containing 2,Bromodomain- and WD repeat-containing protein 2, formerly,BRWD2,BRWD2, formerly,DKFZp434L1715,DR11,FLJ42531,HH14,KIAA1351,WD repeat containing protein 11,WD repeat containing protein 15,WD repeat domain 11,WD repeat domain 15,WDR 11,WDR15
Background: This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene is located in the chromosome 10q25-26 region, which is frequently deleted in gliomas and tumors of other tissues, and is disrupted by the t(10,19) translocation rearrangement in glioblastoma cells. The gene location suggests that it is a candidate gene for the tumor suppressor locus.