Synonyms: Epididymis secretory protein Li 84,FLJ37041,HEL S 84,PIG20,Proliferation inducing gene 20,RCAL,RCN 1,RCN,rcn1,RCN1,Reticulocalbin 1,Reticulocalbin 1 EF hand calcium binding domain,Reticulocalbin-1,Reticulocalbin1
Background: Reticulocalbin 1 is a calcium-binding protein located in the lumen of the ER. The protein contains six conserved regions with similarity to a high affinity Ca(+2)-binding motif, the EF-hand. High conservation of amino acid residues outside of these motifs, in comparison to mouse reticulocalbin, is consistent with a possible biochemical function besides that of calcium binding. In human endothelial and prostate cancer cell lines this protein localizes to the plasma membrane.