RAS Guanyl Releasing Protein 1 (Calcium and DAG-Regulated) (RASGRP1) Antikörper

Details zu Produkt Nr. ABIN6566956
Target
Reaktivität
Human
25
2
2
2
1
1
1
1
Wirt
Kaninchen
25
Klonalität
Polyklonal
Konjugat
Unkonjugiert
3
3
3
2
2
2
Applikation
Western Blotting (WB)
21
18
16
16
1
1
Optionen
Immunogen Recombinant protein of human RASGRP1
Isotyp IgG
Reinigung Affinity purification
Target
Andere Bezeichnung RASGRP1 (RASGRP1 Antibody Abstract)
Hintergrund

Synonyms: Calcium and DAG-regulated guanine nucleotide exchange factor II,CALDAG-GEFI,CalDAG-GEFII,GRP1,Guanine nucleotide exchange factor, calcium and DAG regulated, Rap1A,hRasGRP1,Ras activator RasGRP,RAS guanyl nucleotide releasing protein 1,RAS guanyl releasing protein 1 (calcium and DAG-regulated),RAS guanyl releasing protein 1,RAS guanyl-releasing protein 1,Ras guanyl-releasing protein,RASGRP,rasgrp1,V

Background: This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activates the Erk/MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation. Alternatively spliced transcript variants encoding different isoforms have been identified. Altered expression of the different isoforms of this protein may be a cause of susceptibility to systemic lupus erythematosus (SLE).

Molekulargewicht

Observed_MW: 90kDa

Calculated_MW: 55kDa/62kDa/68kDa/86kDa/90kDa

Gen-ID 10125
UniProt O95267
Pathways T-Zell Rezeptor Signalweg, Fc-epsilon Rezeptor Signalübertragung
Applikations-hinweise WB 1:1000 - 1:2000
Beschränkungen Nur für Forschungszwecke einsetzbar
Konzentration 1 mg/mL
Buffer Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20°C. Avoid freeze / thaw cycles.
Bilder
Image no. 1 for anti-RAS Guanyl Releasing Protein 1 (Calcium and DAG-Regulated) (RASGRP1) antibody (ABIN6566956) Western blot analysis of extracts of various cell lines, using RASGRP1 antibody.