RASGRP1 Antikörper

Produktnummer ABIN6566956

Der Kaninchen-Polyklonal Anti-RASGRP1-Antikörper wurde für WB validiert. Er ist geeignet zum Nachweis von RASGRP1 in Proben aus Human. }

Kurzübersicht für RASGRP1 Antikörper (ABIN6566956)

Target: RASGRP1 (RAS Guanyl Releasing Protein 1 (Calcium and DAG-Regulated) (RASGRP1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RASGRP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-RASGRP1 Antikörper

Aufreinigung: Affinity purification

Immunogen: Recombinant protein of human RASGRP1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:1000 - 1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu RASGRP1

Target: RASGRP1 (RAS Guanyl Releasing Protein 1 (Calcium and DAG-Regulated) (RASGRP1))

Andere Bezeichnung: RASGRP1

Hintergrund:

Synonyms: Calcium and DAG-regulated guanine nucleotide exchange factor II,CALDAG-GEFI,CalDAG-GEFII,GRP1,Guanine nucleotide exchange factor, calcium and DAG regulated, Rap1A,hRasGRP1,Ras activator RasGRP,RAS guanyl nucleotide releasing protein 1,RAS guanyl releasing protein 1 (calcium and DAG-regulated),RAS guanyl releasing protein 1,RAS guanyl-releasing protein 1,Ras guanyl-releasing protein,RASGRP,rasgrp1,V

Background: This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activates the Erk/MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation. Alternatively spliced transcript variants encoding different isoforms have been identified. Altered expression of the different isoforms of this protein may be a cause of susceptibility to systemic lupus erythematosus (SLE).

Molekulargewicht:

Observed_MW: 90kDa

Calculated_MW: 55kDa/62kDa/68kDa/86kDa/90kDa

Gen-ID: 10125

UniProt: O95267

Pathways: T-Zell Rezeptor Signalweg, Fc-epsilon Rezeptor Signalübertragung