Synonyms: activated protease fragment,ATC 2,ATC2,Atrial natriuretic peptide-converting enzyme,Atrial natriuteric peptide converting enzyme,Corin,Corin serine peptidase,CORIN,CRN,Heart specific serine proteinase,Heart specific serine proteinase ATC2,Heart-specific serine proteinase ATC2,MGC119742,Pro ANP convertase,Pro ANP converting enzyme,Pro-ANP-converting enzyme,TMPRSS 10,TMPRSS10,Transmembrane protease serine 10
Background: This gene encodes a member of the type II transmembrane serine protease class of the trypsin superfamily. Members of this family are composed of multiple structurally distinct domains. The encoded protein converts pro-atrial natriuretic peptide to biologically active atrial natriuretic peptide, a cardiac hormone that regulates blood volume and pressure. This protein may also function as a pro-brain-type natriuretic peptide convertase. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.