Synonyms: CA2D3,Cacna2d3,Calcium channel alpha2 delta3 subunit,Calcium channel voltage dependent alpha 2/delta subunit 3,Calcium channel voltage-dependent alpha 2/delta 3 subunit,HSA272268,Voltage dependent calcium channel subunit alpha 2/delta 3,Voltage-dependent calcium channel subunit delta-3,Voltage-gated calcium channel subunit alpha-2/delta-3
Background: This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.