NCOA2 Antikörper (Nuclear Receptor Coactivator 2)

Details for Product anti-NCOA2 Antibody No. ABIN6566851
Target
Reaktivität
Human, Maus, Ratte
58
29
25
5
5
4
4
4
4
2
2
1
1
Wirt
Kaninchen
51
6
1
Klonalität
Polyklonal
Konjugat
Dieser NCOA2 Antikörper ist unkonjugiert
4
3
3
3
3
3
3
2
1
1
1
1
1
1
Applikation
Immunohistochemistry (IHC), Western Blotting (WB)
32
13
12
11
6
5
2
2
2
1
1
1
Optionen
Immunogen Recombinant protein of human NCOA2
Isotyp IgG
Reinigung Affinity purification
Target
Andere Bezeichnung NCOA2 (NCOA2 Antibody Abstract)
Hintergrund

Synonyms: bHLHe75,Class E basic helix-loop-helix protein 75,glucocorticoid receptor interacting protein 1,GRIP 1,GRIP1,hTIF2,MED1,MGC138808,NCoA 2,NCoA-2,Ncoa2,NCOA2,Nuclear receptor coactivator 2,Oncogene FGR,p160,SRC 2,src2,Steroid receptor coactivator 2,TIF 2,TIF2,Transcriptional intermediary factor 2

Background: The protein encoded by this gene functions as a transcriptional coactivator for nuclear hormone receptors, including steroid, thyroid, retinoid, and vitamin D receptors. The encoded protein acts as an intermediary factor for the ligand-dependent activity of these nuclear receptors, which regulate their target genes upon binding of cognate response elements. This gene has been found to be involved in translocations that result in fusions with other genes in various cancers, including the lysine acetyltransferase 6A (KAT6A) gene in acute myeloid leukemia, the ETS variant 6 (ETV6) gene in acute lymphoblastic leukemia, and the hes related family bHLH transcription factor with YRPW motif 1 (HEY1) gene in mesenchymal chondrosarcoma. Alternative splicing results in multiple transcript variants.

Molekulargewicht

Observed_MW: 180kDa

Calculated_MW: 159kDa

Gen-ID 10499
UniProt Q15596
Pathways Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Nuclear Hormone Receptor Binding, Regulation of Lipid Metabolism by PPARalpha, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, CXCR4-mediated Signaling Events, Thromboxane A2 Receptor Signaling
Applikations-hinweise WB 1:500 - 1:2000 IHC 1:50 - 1:200
Beschränkungen Nur für Forschungszwecke einsetzbar
Konzentration 1 mg/mL
Buffer Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20°C. Avoid freeze / thaw cycles.
Bilder
Image no. 1 for anti-Nuclear Receptor Coactivator 2 (NCOA2) antibody (ABIN6566851) Immunohistochemistry of paraffin-embedded rat brain using NCOA2 antibody.
Image no. 2 for anti-Nuclear Receptor Coactivator 2 (NCOA2) antibody (ABIN6566851) Western blot analysis of extracts of various cell lines, using NCOA2 antibody.