CACNA2D2 Antikörper

Produktnummer ABIN6566845

Produktdetails anti-CACNA2D2 Antikörper

Target: CACNA2D2 (Calcium Channel, Voltage-Dependent, alpha 2/delta Subunit 2 (CACNA2D2))

Reaktivität: Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CACNA2D2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: Affinity purification

Immunogen: Recombinant protein of human CACNA2D2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:200 - 1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu CACNA2D2

Target: CACNA2D2 (Calcium Channel, Voltage-Dependent, alpha 2/delta Subunit 2 (CACNA2D2))

Andere Bezeichnung: CACNA2D2 (CACNA2D2 Produkte)

Synonyme: CACNA2D antikoerper, LUAC11.1 antikoerper, Cacna2d antikoerper, a2d2 antikoerper, du antikoerper, mKIAA0558 antikoerper, td antikoerper, torpid antikoerper, calcium voltage-gated channel auxiliary subunit alpha2delta 2 antikoerper, calcium channel, voltage-dependent, alpha 2/delta subunit 2 antikoerper, CACNA2D2 antikoerper, Cacna2d2 antikoerper

Hintergrund:

Synonyms: Alpha 2 delta calcium channel subunit,CA2D2,CACNA2D,Cacna2d2,Calcium channel,voltage-dependent,alpha 2/delta subunit 2,Calcium channel,voltage-dependent,alpha 2/delta subunit 2 gene 26,Calcium voltage gated channel auxiliary subunit alpha2delta 2,Gene 26,KIAA0558,LUAC11.1,Voltage-dependent calcium channel subunit alpha-2/delta-2,Voltage-dependent calcium channel subunit delta-2,Voltage-gated calcium channel subunit alpha-2/delta-2

Background: Calcium channels mediate the entry of calcium ions into the cell upon membrane polarization. This gene encodes the alpha-2/delta subunit of the voltage-dependent calcium channel complex. The complex consists of the main channel-forming subunit alpha-1, and auxiliary subunits alpha-2/delta, beta, and gamma. The auxiliary subunits function in the assembly and membrane localization of the complex, and modulate calcium currents and channel activation/inactivation kinetics. The subunit encoded by this gene undergoes post-translational cleavage to yield the extracellular alpha2 peptide and a membrane-anchored delta polypeptide. This subunit is a receptor for the antiepileptic drug, gabapentin. Mutations in this gene are associated with early infantile epileptic encephalopathy. Single nucleotide polymorphisms in this gene are correlated with increased sensitivity to opioid drugs. Alternative splicing results in multiple transcript variants encoding different isoforms.

Molekulargewicht:

Observed_MW: 140kDa

Calculated_MW: 122kDa/129kDa/130kDa

Gen-ID: 9254

UniProt: Q9NY47

Pathways: Skeletal Muscle Fiber Development