CACNA2D2 Antikörper (Calcium Channel, Voltage-Dependent, alpha 2/delta Subunit 2)

Details for Product anti-CACNA2D2 Antibody No. ABIN6566845
Target
Reaktivität
Maus, Ratte
39
28
12
2
2
1
1
Wirt
Kaninchen
33
9
Klonalität
Polyklonal
Konjugat
Dieser CACNA2D2 Antikörper ist unkonjugiert
3
2
2
2
2
2
1
1
1
1
1
1
Applikation
Western Blotting (WB)
37
25
25
9
7
2
1
1
Optionen
Immunogen Recombinant protein of human CACNA2D2
Isotyp IgG
Reinigung Affinity purification
Target
Andere Bezeichnung CACNA2D2 (CACNA2D2 Antibody Abstract)
Hintergrund

Synonyms: Alpha 2 delta calcium channel subunit,CA2D2,CACNA2D,Cacna2d2,Calcium channel,voltage-dependent,alpha 2/delta subunit 2,Calcium channel,voltage-dependent,alpha 2/delta subunit 2 gene 26,Calcium voltage gated channel auxiliary subunit alpha2delta 2,Gene 26,KIAA0558,LUAC11.1,Voltage-dependent calcium channel subunit alpha-2/delta-2,Voltage-dependent calcium channel subunit delta-2,Voltage-gated calcium channel subunit alpha-2/delta-2

Background: Calcium channels mediate the entry of calcium ions into the cell upon membrane polarization. This gene encodes the alpha-2/delta subunit of the voltage-dependent calcium channel complex. The complex consists of the main channel-forming subunit alpha-1, and auxiliary subunits alpha-2/delta, beta, and gamma. The auxiliary subunits function in the assembly and membrane localization of the complex, and modulate calcium currents and channel activation/inactivation kinetics. The subunit encoded by this gene undergoes post-translational cleavage to yield the extracellular alpha2 peptide and a membrane-anchored delta polypeptide. This subunit is a receptor for the antiepileptic drug, gabapentin. Mutations in this gene are associated with early infantile epileptic encephalopathy. Single nucleotide polymorphisms in this gene are correlated with increased sensitivity to opioid drugs. Alternative splicing results in multiple transcript variants encoding different isoforms.

Molekulargewicht

Observed_MW: 140kDa

Calculated_MW: 122kDa/129kDa/130kDa

Gen-ID 9254
UniProt Q9NY47
Pathways Skeletal Muscle Fiber Development
Applikations-hinweise WB 1:200 - 1:2000
Beschränkungen Nur für Forschungszwecke einsetzbar
Konzentration 1 mg/mL
Buffer Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20°C. Avoid freeze / thaw cycles.
Bilder
Image no. 1 for anti-Calcium Channel, Voltage-Dependent, alpha 2/delta Subunit 2 (CACNA2D2) antibody (ABIN6566845) Western blot analysis of extracts of various cell lines, using CACNA2D2 antibody.