Synonyms: CRL 4,CRL4,Cytokine receptor CRL4,EVI 27,EVI27,IL 17 receptor B,IL 17 receptor homolog 1,IL 17B receptor,IL 17RB,IL 17Rh1,IL17BR,IL17RB,IL17RH1,Interleukin 17 receptor B,Interleukin 17 receptor homolog 1,Interleukin 17 receptor homolog,Interleukin 17B receptor,MGC5245
Background: The protein encoded by this gene is a cytokine receptor. This receptor specifically binds to IL17B and IL17E, but does not bind to IL17 and IL17C. This receptor has been shown to mediate the activation of NF-kappaB and the production of IL8 induced by IL17E. The expression of the rat counterpart of this gene was found to be significantly up-regulated during intestinal inflammation, which suggested the immunoregulatory activity of this receptor.