Synonyms: 190 kDa form stabilin-2,190 kDa hyaluronan receptor for endocytosis,EGF-like,FAS1 EGF-like and X-link domain-containing adhesion molecule 2,Fasciclin,FEEL-2,FEEL2,FELL,FEX2,HARE,Hyaluronan receptor for endocytosis,laminin-type EGF-like and link domain-containing scavenger receptor 2,link domain-containing scavenger receptor 2,STAB-2,Stab2,STAB2
Background: This gene encodes a large, transmembrane receptor protein which may function in angiogenesis, lymphocyte homing, cell adhesion, or receptor scavenging. The protein contains 7 fasciclin, 15 epidermal growth factor (EGF)-like, and 2 laminin-type EGF-like domains as well as a C-type lectin-like hyaluronan-binding Link module. The protein is primarily expressed on sinusoidal endothelial cells of liver, spleen, and lymph node. The receptor has been shown to bind and endocytose ligands such as hyaluronan, low density lipoprotein, Gram-positive and Gram-negative bacteria, and advanced glycosylation end products. Supporting its possible role as a scavenger receptor, the protein has been shown to cycle between the plasma membrane and lysosomes.