Synonyms: CANDF5,CD217,CD217 antigen,CDw217,CTLA8,HIL 17R,hIL17R,I17RA,IL 17 receptor A,IL 17 receptor,IL 17RA,IL-17 receptor A,IL-17RA,IL17,IL17A receptor,IL17R,IL17RA,IMD51,Interleukin 17 receptor A,Interleukin-17 receptor A,MGC10262
Background: Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The transmembrane protein encoded by this gene (interleukin 17A receptor, IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Alternative splicing results in multiple transcript variants encoding different isoforms.