Synonyms: A disintegrin and metalloproteinase domain 22,ADA22,ADAM 22,ADAM metallopeptidase domain 22,adam22,and cysteine-rich protein 2,Disintegrin and metalloproteinase domain-containing protein 22,disintegrin-like,MDC 2,MDC2,Metalloproteinase disintegrin ADAM22 3,Metalloproteinase like disintegrin like and cysteine rich protein 2,Metalloproteinase-disintegrin ADAM22-3,Metalloproteinase-like,MGC149832
Background: This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Unlike other members of the ADAM protein family, the protein encoded by this gene lacks metalloprotease activity since it has no zinc-binding motif. This gene is highly expressed in the brain and may function as an integrin ligand in the brain. In mice, it has been shown to be essential for correct myelination in the peripheral nervous system. Alternative splicing results in several transcript variants.