Synonyms: ACAD3,ACADS,ACADS,Acyl Coenzyme A dehydrogenase,C2 to C3 short chain,Acyl-CoA dehydrogenase,C2 to C3 short chain,Acyl-CoA dehydrogenase,short chain,Acyl-Coenzyme A dehydrogenase,short chain,AI196007,Bcd-1,Bcd1,Butyryl CoA dehydrogenase,Butyryl-CoA dehydrogenase,EC 220.127.116.11,mitochondrial,SCAD,Short chain acyl CoA dehydrogenase,Short-chain specific acyl-CoA dehydrogenase,Short-chain specific acyl-CoA dehydrogenase,mitochondrial,Unsaturated acyl CoA reductase
Background: This gene encodes a tetrameric mitochondrial flavoprotein, which is a member of the acyl-CoA dehydrogenase family. This enzyme catalyzes the initial step of the mitochondrial fatty acid beta-oxidation pathway. Mutations in this gene have been associated with short-chain acyl-CoA dehydrogenase (SCAD) deficiency. Alternative splicing results in two variants which encode different isoforms.