PKN1 Antikörper (Protein Kinase N1)

Details for Product anti-PKN1 Antibody No. ABIN6566611
Target
Reaktivität
Human, Maus, Ratte
40
10
8
4
4
4
2
1
1
Wirt
Kaninchen
28
13
Klonalität
Polyklonal
Konjugat
Dieser PKN1 Antikörper ist unkonjugiert
2
2
2
2
2
2
2
Applikation
Immunohistochemistry (IHC), Western Blotting (WB)
29
10
7
7
5
5
4
4
3
1
1
1
Optionen
Immunogen Recombinant protein of human PKN1
Isotyp IgG
Reinigung Affinity purification
Target
Andere Bezeichnung PKN1 (PKN1 Antibody Abstract)
Hintergrund

Synonyms: DBK,DPKN,PAK 1,PRK 1,PROTEIN KINASE C RELATED KINASE 1,SERINE/THREONINE PROTEIN KINASE N

Background: The protein encoded by this gene belongs to the protein kinase C superfamily. This kinase is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can be activated by phospholipids and by limited proteolysis. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
Molekulargewicht

Observed_MW: 120kDa

Calculated_MW: 104kDa
Gen-ID 5585
UniProt Q16512
Applikations-hinweise WB 1:500 - 1:1000 IHC 1:50 - 1:100
Beschränkungen Nur für Forschungszwecke einsetzbar
Konzentration 1 mg/mL
Buffer Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20°C. Avoid freeze / thaw cycles.
Bilder
Image no. 1 for anti-Protein Kinase N1 (PKN1) antibody (ABIN6566611) Western blot analysis of extracts of various cell lines, using PKN1 antibody.
Image no. 2 for anti-Protein Kinase N1 (PKN1) antibody (ABIN6566611) Immunohistochemistry of paraffin-embedded mouse brain using PKN1 antibody.
Image no. 3 for anti-Protein Kinase N1 (PKN1) antibody (ABIN6566611) Immunohistochemistry of paraffin-embedded human lung using PKN1 antibody.