PSME3 Antikörper

Produktnummer ABIN6566551

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch PSME3 in WB und IF. Er zeigt eine Reaktivität gegenüber Human und Ratte.

Kurzübersicht für PSME3 Antikörper (ABIN6566551)

Target: PSME3

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PSME3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Produktdetails anti-PSME3 Antikörper

Aufreinigung: Affinity purification

Immunogen: Recombinant protein of human PSME3

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500 - 1:2000 IF 1:20 - 1:50

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu PSME3

Target: PSME3

Andere Bezeichnung: PSME3

Hintergrund:

Synonyms: 11S regulator complex gamma subunit,11S regulator complex subunit gamma,Activator of multicatalytic protease subunit 3,Ki,Ki antigen,Ki nuclear autoantigen,Ki,PA28 gamma,PA28 gamma,PA28g,PA28gamma,Proteasome (prosome,macropain) activator subunit 3 (PA28 gamma,Ki),Proteasome (prosome,macropain) activator subunit 3,Proteasome activator 28 gamma,Proteasome activator 28 subunit gamma,Proteasome activator complex subunit 3,Proteasome activator subunit 3,PSME3,PSME3,REG GAMMA,REG-gamma

Background: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits, 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the gamma subunit of the 11S regulator. Six gamma subunits combine to form a homohexameric ring. Alternate splicing results in multiple transcript variants.

Molekulargewicht:

Observed_MW: 32kDa

Calculated_MW: 29kDa/30kDa

Gen-ID: 10197

UniProt: P61289

Pathways: Mitotic G1-G1/S Phases, DNA Replication, Positive Regulation of Endopeptidase Activity, Hepatitis C, Synthesis of DNA