BCR Antikörper (Breakpoint Cluster Region)

Details for Product anti-BCR Antibody No. ABIN6566471
Target
Reaktivität
Human, Maus, Ratte
131
109
60
6
6
2
2
2
1
1
1
Wirt
Kaninchen
122
15
1
Klonalität
Polyklonal
Konjugat
Dieser BCR Antikörper ist unkonjugiert
11
8
5
5
5
5
5
3
3
3
3
3
3
3
3
1
Applikation
Immunohistochemistry (IHC), Western Blotting (WB)
76
47
41
39
23
19
12
10
4
3
2
2
1
1
Optionen
Immunogen Recombinant protein of human BCR
Isotyp IgG
Reinigung Affinity purification
Target
Andere Bezeichnung BCR (BCR Antibody Abstract)
Hintergrund

Synonyms: ALL,bcr,BCR/ABL FUSION GENE,INCLUDED,BCR/FGFR1 chimera protein,BCR/FGFR1 FUSION GENE,INCLUDED,BCR/PDGFRA FUSION GENE,INCLUDED,BCR,BCR1,Breakpoint cluster region,Breakpoint cluster region protein,CML,D22S11,D22S662,FGFR1/BCR chimera protein,PHL,Renal carcinoma antigen NY-REN-26

Background: A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene.
Molekulargewicht

Observed_MW: 150kDa

Calculated_MW: 137kDa/142kDa
Gen-ID 613
UniProt P11274
Pathways Regulation of Leukocyte Mediated Immunity, Platelet-derived growth Factor Receptor Signaling
Applikations-hinweise WB 1:500 - 1:2000 IHC 1:50 - 1:100
Beschränkungen Nur für Forschungszwecke einsetzbar
Konzentration 1 mg/mL
Buffer Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20°C. Avoid freeze / thaw cycles.
Bilder
Image no. 1 for anti-Breakpoint Cluster Region (BCR) antibody (ABIN6566471) Western blot analysis of extracts of various cell lines, using BCR antibody.
Image no. 2 for anti-Breakpoint Cluster Region (BCR) antibody (ABIN6566471) Immunohistochemistry of paraffin-embedded human prostate using BCR antibody.
Image no. 3 for anti-Breakpoint Cluster Region (BCR) antibody (ABIN6566471) Immunohistochemistry of paraffin-embedded human stomach using BCR antibody.