PC (AA 53-82), (N-Term) Antikörper

Produktnummer ABIN656425

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch in WB und IHC (p). Er zeigt eine Reaktivität gegenüber Maus.

Kurzübersicht für PC (AA 53-82), (N-Term) Antikörper (ABIN656425)

Target: PC

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: RB31105

Produktdetails

Bindungsspezifität: AA 53-82, N-Term

Spezifität: This PC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 52-82 amino acids from the N-terminal region of human PC.

Homologie: Cow (Bovine),Rat (Rattus)

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This PC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 53-82 AA from the N-terminal region of human PC.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB = 1:1000, IHC (p) = 1:10-50

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: PBS with 0.09 % (W/V) sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: PC Antibody (N-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.

Haltbarkeit: 6 months

Antigendetails

Target: PC

Hintergrund: This gene encodes pyruvate carboxylase, which requires biotin and ATP to catalyse the carboxylation of pyruvate to oxaloacetate. The active enzyme is a homotetramer arranged in a tetrahedron which is located exclusively in the mitochondrial matrix. Pyruvate carboxylase is involved in gluconeogenesis, lipogenesis, insulin secretion and synthesis of the neurotransmitter glutamate. Mutations in this gene have been associated with pyruvate carboxylase deficiency. Alternatively spliced transcript variants with different 5' UTRs, but encoding the same protein, have been found for this gene. [provided by RefSeq].
Synonyms: Pyruvate carboxylase, mitochondrial,PC,

Molekulargewicht: 129634 DA

Gen-ID: 5091

NCBI Accession: NP_000911, NP_001035806, NP_071504

UniProt: P11498