GSAP Antikörper (C-Term)
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- Target Alle GSAP (PION) Antikörper anzeigen
- GSAP (PION) (Pigeon Homolog (PION))
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Bindungsspezifität
- AA 537-565, C-Term
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser GSAP Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Aufreinigung
- This antibody is purified through a protein A column, followed by peptide affinity purification.
- Immunogen
- This PION antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 537-565 amino acids from the C-terminal region of human PION.
- Klon
- RB27384
- Isotyp
- IgG
- Top Product
- Discover our top product PION Primärantikörper
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- Applikationshinweise
- WB: 1:1000. IHC-P: 1:10~50
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Buffer
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C,-20 °C
- Informationen zur Lagerung
- PION Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
- Haltbarkeit
- 6 months
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- Target
- GSAP (PION) (Pigeon Homolog (PION))
- Andere Bezeichnung
- PION (PION Produkte)
- Synonyme
- PION antikoerper, A530088I07Rik antikoerper, Pion antikoerper, gamma-secretase activating protein antikoerper, GSAP antikoerper, Gsap antikoerper
- Hintergrund
- Accumulation of neurotoxic amyloid-beta is a major hallmark of Alzheimer disease (AD, MIM 104300). Formation of amyloid-beta is catalyzed by gamma-secretase (see PSEN1, MIM 104311), a protease with numerous substrates. PION, or GSAP, selectively increases amyloid-beta production through a mechanism involving its interaction with both gamma-secretase and its substrate, the amyloid-beta precursor protein (APP, MIM 104760) C-terminal fragment (APP-CTF) (He et al., 2010 [PubMed 20811458]).
- Molekulargewicht
- 97802
- Gen-ID
- 54103
- NCBI Accession
- NP_059135
- UniProt
- A4D1B5
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