SESN3 Antikörper (AA 320-347)

Produktnummer ABIN656403

Dieses Anti-SESN3-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von SESN3 in WB und IHC (p). Geeignet für Human. Dieses Primary Antibody wurde in 2+ Publikationen zitiert.

Kurzübersicht für SESN3 Antikörper (AA 320-347) (ABIN656403)

Target: SESN3 (Sestrin 3 (SESN3))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SESN3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: RB18605

Produktdetails anti-SESN3 Antikörper

Bindungsspezifität: AA 320-347

Homologie: M

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This Sestrin-3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 320-347 amino acids from the Central region of human Sestrin-3.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. WB: 1:2000. IHC-P: 1:10~50

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Sestrin-3 Antibody (Center Y335) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.

Haltbarkeit: 6 months

Referenzen für anti-SESN3 Antikörper (ABIN656403)

Kimball, Ravi, Gordon, Dennis, Jefferson: "Amino Acid-Induced Activation of mTORC1 in Rat Liver Is Attenuated by Short-Term Consumption of a High-Fat Diet." in: The Journal of nutrition, Vol. 145, Issue 11, pp. 2496-502, (2015) (PubMed).

Ye, Palm, Peng, King, Lindsten, Li, Koumenis, Thompson: "GCN2 sustains mTORC1 suppression upon amino acid deprivation by inducing Sestrin2." in: Genes & development, Vol. 29, Issue 22, pp. 2331-6, (2015) (PubMed).

Details zu SESN3

Target: SESN3 (Sestrin 3 (SESN3))

Andere Bezeichnung: Sestrin-3

Hintergrund: Sestrins form a small family of redox enzymes which regulate accumulation of Reactive Oxygen Species. They protect cells and their DNA against oxidative damage and regulate cell growth and viability. These genes are often deregulated in cancers and their inactivation accelerates the growth of model tumors in mice.

Molekulargewicht: 57291

Gen-ID: 143686

NCBI Accession: NP_653266

UniProt: P58005