SMPD1 Antikörper (C-Term)

Produktnummer ABIN656161

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch SMPD1 in WB, FACS und IHC (p). Er zeigt eine Reaktivität gegenüber Human und wurde in 1 Publikation erwähnt.

Kurzübersicht für SMPD1 Antikörper (C-Term) (ABIN656161)

Target: SMPD1 (Sphingomyelin phosphodiesterase 1, Acid Lysosomal (SMPD1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SMPD1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: RB31029

Produktdetails anti-SMPD1 Antikörper

Bindungsspezifität: AA 391-419, C-Term

Homologie: B

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This SMPD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 391-419 amino acids from the C-terminal region of human SMPD1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:2000. WB: 1:4000. IHC-P-Leica: 1:500. IHC-P-Leica: 1:500. FC: 1:25

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: SMPD1 Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.

Haltbarkeit: 6 months

Referenzen für anti-SMPD1 Antikörper (ABIN656161)

Ullio, Casas, Brunk, Sala, Fabriàs, Ghidoni, Bonelli, Baccino, Autelli: "Sphingosine mediates TNF?-induced lysosomal membrane permeabilization and ensuing programmed cell death in hepatoma cells." in: Journal of lipid research, Vol. 53, Issue 6, pp. 1134-43, (2012) (PubMed).

Details zu SMPD1

Target: SMPD1 (Sphingomyelin phosphodiesterase 1, Acid Lysosomal (SMPD1))

Andere Bezeichnung: SMPD1

Hintergrund: The protein encoded by this gene is a lysosomal acid sphingomyelinase that converts sphingomyelin to ceramide. The encoded protein also has phospholipase C activity. Defects in this gene are a cause of Niemann-Pick disease type A (NPA) and Niemann-Pick disease type B (NPB). Multiple transcript variants encoding different isoforms have been identified. [provided by RefSeq].

Molekulargewicht: 69936

Gen-ID: 6609

NCBI Accession: NP_000534, NP_001007594

UniProt: P17405