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TRIM72 Antikörper (C-Term)

Der Kaninchen Polyklonal Anti-TRIM72-Antikörper wurde für WB und IHC (p) validiert. Er ist geeignet, TRIM72 in Proben von Human, Ratte und Maus zu detektieren.
Produktnummer ABIN655919

Kurzübersicht für TRIM72 Antikörper (C-Term) (ABIN655919)

Target

Alle TRIM72 Antikörper anzeigen
TRIM72 (Tripartite Motif Containing 72 (TRIM72))

Reaktivität

  • 26
  • 8
  • 7
  • 4
  • 4
  • 3
  • 2
  • 2
  • 2
  • 2
Human, Ratte, Maus

Wirt

  • 20
  • 5
  • 2
Kaninchen

Klonalität

  • 24
  • 3
Polyklonal

Konjugat

  • 20
  • 2
  • 2
  • 1
  • 1
  • 1
Dieser TRIM72 Antikörper ist unkonjugiert

Applikation

  • 24
  • 15
  • 13
  • 4
  • 3
  • 1
  • 1
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon

RB29696
  • Bindungsspezifität

    • 7
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 299-327, C-Term

    Aufreinigung

    This antibody is purified through a protein A column, followed by peptide affinity purification.

    Immunogen

    This TRIM72 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 299-327 amino acids from the C-terminal region of human TRIM72.

    Isotyp

    Ig Fraction
  • Applikationshinweise

    WB: 1:2000. IHC-P: 1:10~50

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

    Haltbarkeit

    6 months
  • Target

    TRIM72 (Tripartite Motif Containing 72 (TRIM72))

    Andere Bezeichnung

    TRIM72

    Hintergrund

    TRIM72 is a muscle-specific protein that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites. Specifically binds phosphatidylserine. Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site. This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch formation. Probably acts upstream of the Ca(2+)-dependent membrane resealing process. Required for transport of DYSF to sites of cell injury during repair patch formation. Regulates membrane budding and exocytosis. May be involved in the regulation of the mobility of KCNB1-containing endocytic vesicles (By similarity).

    Molekulargewicht

    52731

    Gen-ID

    493829

    NCBI Accession

    NP_001008275

    UniProt

    Q6ZMU5
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