MITF Antikörper (N-Term)

Produktnummer ABIN655506

Produktdetails anti-MITF Antikörper

Target: MITF (Microphthalmia-Associated Transcription Factor (MITF))

Bindungsspezifität: AA 1-28, N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MITF Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS)

Homologie: M, Rat

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This MITF antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-28 amino acids from the N-terminal region of human MITF.

Klon: RB18810

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: IF: 1:10~50. WB: 1:1000. WB: 1:2000. IHC: 1:800. FC: 1:10~50

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Referenzen für anti-MITF Antikörper (ABIN655506)

Ishii, Ryu, Suzuki: "Lactoferrin inhibits melanogenesis by down-regulating MITF in melanoma cells and normal melanocytes." in: Biochemistry and cell biology = Biochimie et biologie cellulaire, Vol. 95, Issue 1, pp. 119-125, (2017) (PubMed).

Details zu MITF

Target: MITF (Microphthalmia-Associated Transcription Factor (MITF))

Andere Bezeichnung: MITF (MITF Produkte)

Hintergrund: This gene encodes a transcription factor that contains both basic helix-loop-helix and leucine zipper structural features. It regulates the differentiation and development of melanocytes retinal pigment epithelium and is also responsible for pigment cell-specific transcription of the melanogenesis enzyme genes. Heterozygous mutations in the this gene cause auditory-pigmentary syndromes, such as Waardenburg syndrome type 2 and Tietz syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified.

Molekulargewicht: 58795

Gen-ID: 4286

NCBI Accession: NP_000239, NP_001171896, NP_006713, NP_937801, NP_937802, NP_937820, NP_937821

UniProt: O75030

Pathways: Chromatin Binding