DENND1B Antikörper (N-Term)

Produktnummer ABIN654339

Dieses Anti-DENND1B-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von DENND1B in WB, FACS und IHC (p). Geeignet für Human.

Kurzübersicht für DENND1B Antikörper (N-Term) (ABIN654339)

Target: DENND1B (DENN/MADD Domain Containing 1B (DENND1B))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DENND1B Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: RB28056

Produktdetails anti-DENND1B Antikörper

Bindungsspezifität: AA 39-68, N-Term

Homologie: M

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This DENND1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 39-68 amino acids from the N-terminal region of human DENND1B.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:500. WB: 1:1000. IHC-P: 1:50~100. FC: 1:10~50

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Details zu DENND1B

Target: DENND1B (DENN/MADD Domain Containing 1B (DENND1B))

Andere Bezeichnung: DENND1B

Hintergrund: Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1B, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2, see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 [PubMed 20154091]).

Molekulargewicht: 86552

Gen-ID: 163486

NCBI Accession: NP_001182144, NP_001182145, NP_659414

UniProt: Q6P3S1