Importin 11 Antikörper (C-Term)

Produktnummer ABIN653614

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch Importin 11 in WB. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für Importin 11 Antikörper (C-Term) (ABIN653614)

Target: Importin 11 (IPO11)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Importin 11 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: RB24373

Produktdetails anti-Importin 11 Antikörper

Bindungsspezifität: AA 891-920, C-Term

Homologie: M

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This IPO11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 891-920 amino acids from the C-terminal region of human IPO11.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Details zu Importin 11

Target: Importin 11 (IPO11)

Andere Bezeichnung: IPO11

Hintergrund: IPO11 functions in nuclear protein import as nuclear transport receptor. It serves as receptor for nuclear localization signals (NLS) in cargo substrates and is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP-and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). It mediates the nuclear import of UBE2E3, and of RPL12 (By similarity).

Molekulargewicht: 112535

Gen-ID: 51194

NCBI Accession: NP_001128251, NP_057422

UniProt: Q9UI26

Pathways: Protein targeting to Nucleus