ANGPTL4 Antikörper (AA 138-167)

Produktnummer ABIN653155

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch ANGPTL4 in WB, FACS und IHC (p). Er zeigt eine Reaktivität gegenüber Human und wurde in 2+ Publikationen erwähnt.

Kurzübersicht für ANGPTL4 Antikörper (AA 138-167) (ABIN653155)

Target: ANGPTL4 (Angiopoietin-Like 4 (ANGPTL4))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ANGPTL4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: RB18264

Produktdetails anti-ANGPTL4 Antikörper

Bindungsspezifität: AA 138-167

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This ANGPTL4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 138-167 amino acids from the Central region of human ANGPTL4.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. IHC-P: 1:50~100. FC: 1:25

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Referenzen für anti-ANGPTL4 Antikörper (ABIN653155)

Huang, Xie, Lin, Li, Huang, Wang, Ye: "The downregulation of ANGPTL4 inhibits the migration and proliferation of tongue squamous cell carcinoma." in: Archives of oral biology, Vol. 71, pp. 144-149, (2017) (PubMed).

Wan, Wen, Dong, Tang, Liu, Liu, Tao, Gao, Sun, Cao, Fan, Wu: "Establishment of monoclonal HCC cell lines with organ site-specific tropisms." in: BMC cancer, Vol. 15, pp. 678, (2015) (PubMed).

Details zu ANGPTL4

Target: ANGPTL4 (Angiopoietin-Like 4 (ANGPTL4))

Andere Bezeichnung: ANGPTL4

Hintergrund: ANGPTL4 is a member of the angiopoietin/angiopoietin-like gene family and encodes a glycosylated, secreted protein with a fibrinogen C-terminal domain. This protein is induced under hypoxic conditions in endothelial cells and is the target of peroxisome proliferation activators. The encoded protein is a serum hormone directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity and also acts as an apoptosis survival factor for vascular endothelial cells. The encoded protein may play a role in several cancers and it also has been shown to prevent the metastatic process by inhibiting vascular activity as well as tumor cell motility and invasiveness. Decreased expression of this protein has been associated with type 2 diabetes.

Molekulargewicht: 45214

Gen-ID: 51129

NCBI Accession: NP_001034756, NP_647475

UniProt: Q9BY76

Pathways: Regulation of Lipid Metabolism by PPARalpha