HAS2 Antikörper (AA 138-166)

Produktnummer ABIN651874

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch HAS2 in WB, FACS und IHC (p). Er zeigt eine Reaktivität gegenüber Human und Maus und wurde in 2+ Publikationen erwähnt.

Kurzübersicht für HAS2 Antikörper (AA 138-166) (ABIN651874)

Target: HAS2 (Hyaluronan Synthase 2 (HAS2))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HAS2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: RB22492

Produktdetails anti-HAS2 Antikörper

Bindungsspezifität: AA 138-166

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This HAS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 138-166 amino acids of human HAS2.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. IHC-P: 1:25. IHC-P: 1:50~100. FC: 1:10~50

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid freeze-thaw cycles.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots.

Haltbarkeit: 6 months

Referenzen für anti-HAS2 Antikörper (ABIN651874)

Lien, Lee, Jeng, Lin, Lu, Yao: "Differential expression of hyaluronan synthase 2 in breast carcinoma and its biological significance." in: Histopathology, Vol. 65, Issue 3, pp. 328-39, (2015) (PubMed).

Kobayashi, Banno, Shimizu, Ueki, Tsuji, Masuda, Kisu, Nomura, Tominaga, Nagano, Saya, Aoki: "Gene expression profile of a newly established choriocarcinoma cell line, iC3-1, compared to existing choriocarcinoma cell lines and normal placenta." in: Placenta, Vol. 34, Issue 2, pp. 110-8, (2013) (PubMed).

Details zu HAS2

Target: HAS2 (Hyaluronan Synthase 2 (HAS2))

Andere Bezeichnung: HAS2

Hintergrund: Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis. HAS2 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to glycosaminoglycan synthetase (DG42) from Xenopus laevis, and human and murine hyaluronan synthase 1.

Molekulargewicht: 63566

Gen-ID: 3037

NCBI Accession: NP_005319

UniProt: Q92819

Pathways: Glycosaminoglycan Metabolic Process