PDX1 Antikörper (pThr11)

Produktnummer ABIN650810

Der Kaninchen Polyklonal Anti-PDX1 Antikörper wurde für IF und DB validiert. Er ist geeignet, PDX1 in Proben von Human zu detektieren.

Kurzübersicht für PDX1 Antikörper (pThr11) (ABIN650810)

Target: PDX1 (Pancreatic and Duodenal Homeobox 1 (PDX1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PDX1 Antikörper ist unkonjugiert

Applikation: Immunofluorescence (IF), Dot Blot (DB)

Klon: RB15204

Produktdetails anti-PDX1 Antikörper

Bindungsspezifität: pThr11

Homologie: M, Rat

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This PDX1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T11 of human PDX1.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: IF: 1:100. DB: 1:500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Details zu PDX1

Target: PDX1 (Pancreatic and Duodenal Homeobox 1 (PDX1))

Andere Bezeichnung: PDX1

Hintergrund: PDX1 is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. The encoded nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in this protein are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (NIDDM), as well as maturity onset diabetes of the young type 4 (MODY4).

Molekulargewicht: 30771

Gen-ID: 3651

NCBI Accession: NP_000200

UniProt: P52945

Pathways: Nuclear Receptor Transcription Pathway, Positive Regulation of Peptide Hormone Secretion, Steroid Hormone Mediated Signaling Pathway, Hormone Transport, Carbohydrate Homeostasis, Chromatin Binding, Maintenance of Protein Location