MBP Antikörper (AA 177-209)

Produktnummer ABIN650720

Der Kaninchen Polyklonal Anti-MBP-Antikörper wurde für WB validiert. Er ist geeignet, MBP in Proben von Human zu detektieren.

Kurzübersicht für MBP Antikörper (AA 177-209) (ABIN650720)

Target: MBP

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MBP Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: RB15523

Produktdetails anti-MBP Antikörper

Bindungsspezifität: AA 177-209

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This MBP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 177-209 amino acids from human MBP.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:16000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Details zu MBP

Target: MBP

Hintergrund: MBP is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called Golli-MBP) that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes.

Molekulargewicht: 33117

Gen-ID: 4155

NCBI Accession: NP_001020252, NP_001020261, NP_001020263, NP_001020271, NP_001020272, NP_002376

UniProt: P02686