Natural Killer Cells Antikörper

Produktnummer ABIN642458

Der Maus Monoklonal anti-Natural Killer Cells Antikörper wird verwendet zum Nachweis von Natural Killer Cells in Proben von Maus. Er wurde validiert für Func, FACS und IP.

Kurzübersicht für Natural Killer Cells Antikörper (ABIN642458)

Target: Natural Killer Cells

Reaktivität: Maus

Wirt: Maus

Klonalität: Monoklonal

Applikation: Functional Studies (Func), Flow Cytometry (FACS), Immunoprecipitation (IP)

Produktdetails

Verwendungszweck: Mouse Anti-Mouse NK-1.1 Ag.

Spezifität: DS-MB-02011 recognizes the mouse NK1.1 cell surface antigen, a cell surface glycoprotein encoded by members of the NKR-P1 gene family.In the mouse the NKR-P1 family has three members, NKR-P1A, -B and -C, whilst in the human only one member has been identified. The human protein has received the designation CD161, and the mouse proteins have been referred to as CD161a, -b, -c etc. Although previously thought to recognize only CD161c, recent data has shown that this antibody may also react with CD161b. CD161c expression itself is strain specific in mice, but recognition of CD161b by DS-MB-2011 appears to be even more complex, as only some CD161b positive strains are labeled by the antibody. Engagement of CD161c has been reported to have activating function in NK cells, whilst engagement of CD161b is inhibitory. DS-MB-02011 is useful for the identification of NK cells in selected strains of mice (positive on C57BL, FVB/N and NZB, but negative on AKR and BALB/c) and is also expressed by rare subsets of T cells and monocytes. The antibody has also been used for in vivo depletion of NK cells and in vitro activation of NK cells.

Immunogen: Spleen and bone marrow cells from CE mice

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: Flow Cytometry, Functional Assays, Immunoprecipitation

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: IgG concentration 1.0 mg/ml

Buffer: Phosphate buffered saline, pH 7.4

Konservierungsmittel: Azide free

Lagerung: -20 °C

Informationen zur Lagerung: -20°C

Antigendetails

Target: Natural Killer Cells