Adipolean (Variant) Antikörper

Produktnummer ABIN636638

Der Kaninchen Polyklonal Anti--Antikörper wurde für ELISA, WB und Inhibition validiert. Er ist geeignet, in Proben von Human zu detektieren.

Kurzübersicht für Adipolean (Variant) Antikörper (ABIN636638)

Target: Adipolean

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Unkonjugiert

Applikation: ELISA, Western Blotting (WB), Blocking Antibody (Inhibition)

Produktdetails

Bindungsspezifität: Variant

Aufreinigung: Purified

Immunogen: Adipolean Variant antibody was raised in rabbit using highly pure recombinant human adipolean variant as the immunogen.

Anwendungsinformationen

Applikationshinweise: Optimal conditions should be determined byt he investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Konzentration: Lot specific

Buffer: Lyophilized from PBS, pH 7.2.

Handhabung: Avoid repeated freeze/thaw cycles.
Dilute only prior to immediate use.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at -20 °C until reconstitution. Following reconstitution product may be stored at 4 °C in the short term. For long term storage aliquot and freeze at -20 °C.

Antigendetails

Target: Adipolean

Hintergrund: The adipolean variant is an important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. It stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. The adipolean variant antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. It also inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway.