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INSIG1 Antikörper (Middle Region)

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch INSIG1 in WB. Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte.
Produktnummer ABIN635167

Kurzübersicht für INSIG1 Antikörper (Middle Region) (ABIN635167)

Target

Alle INSIG1 Antikörper anzeigen
INSIG1 (Insulin Induced Gene 1 (INSIG1))

Reaktivität

  • 26
  • 9
  • 7
  • 4
  • 4
  • 4
  • 4
  • 3
  • 3
  • 3
  • 3
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
Human, Maus, Ratte

Wirt

  • 27
Kaninchen

Klonalität

  • 27
Polyklonal

Konjugat

  • 20
  • 3
  • 1
  • 1
  • 1
  • 1
Dieser INSIG1 Antikörper ist unkonjugiert

Applikation

  • 23
  • 15
  • 10
  • 6
  • 4
  • 3
  • 3
  • 1
Western Blotting (WB)
  • Bindungsspezifität

    • 7
    • 6
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Middle Region

    Spezifität

    INSIG1 antibody was raised against the middle region of INSIG1

    Aufreinigung

    Affinity purified

    Immunogen

    INSIG1 antibody was raised using the middle region of INSIG1 corresponding to a region with amino acids WWVPPCCGTASAVIGLLYPCIDRHLGEPHKFKREWSSVMRCVAVFVGINH
  • Applikationshinweise

    WB: 1 µg/mL
    Optimal conditions should be determined by the investigator.

    Kommentare

    INSIG1 Blocking Peptide, catalog no. 33R-10042, is also available for use as a blocking control in assays to test for specificity of this INSIG1 antibody

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Lyophilized powder. Add distilled water for a 1 mg/mL concentration of INSIG1 antibody in PBS

    Konzentration

    Lot specific

    Buffer

    PBS

    Handhabung

    Avoid repeated freeze/thaw cycles.
    Dilute only prior to immediate use.

    Lagerung

    4 °C/-20 °C

    Informationen zur Lagerung

    Store at 2-8 °C for short periods. For longer periods of storage, store at -20 °C.
  • Target

    INSIG1 (Insulin Induced Gene 1 (INSIG1))

    Andere Bezeichnung

    INSIG1

    Hintergrund

    Oxysterols regulate cholesterol homeostasis through the liver X receptor (LXR)- and sterol regulatory element-binding protein (SREBP)-mediated signaling pathways. This gene is an insulin-induced gene. INSIG1 is an endoplasmic reticulum (ER) membrane protein that plays a critical role in regulating cholesterol concentrations in cells. INSIG1 binds to the sterol-sensing domains of SREBP cleavage-activating protein (SCAP) and HMG CoA reductase, and is essential for the sterol-mediated trafficking of the two proteins.

    Molekulargewicht

    25 kDa (MW of target protein)

    Pathways

    ER-Nucleus Signaling
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