Erythrocyte Ankyrin Antikörper (C-Term)

Produktnummer ABIN630429

Dieses Anti-Erythrocyte Ankyrin-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von Erythrocyte Ankyrin in WB und IHC. Geeignet für Human, Maus, Ratte und Hund.

Kurzübersicht für Erythrocyte Ankyrin Antikörper (C-Term) (ABIN630429)

Target: Erythrocyte Ankyrin (ANK1) (Ankyrin 1, Erythrocytic (ANK1))

Reaktivität: Human, Maus, Ratte, Hund

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Erythrocyte Ankyrin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-Erythrocyte Ankyrin Antikörper

Bindungsspezifität: C-Term

Spezifität: Ankyrin 1 antibody was raised against the C terminal of ANK1

Aufreinigung: Purified

Immunogen: Ankyrin 1 antibody was raised using the C terminal of ANK1 corresponding to a region with amino acids VVRQIDLSSADAAQEHEEVELRGSGLQPDLIEGRKGAQIVKRASLKRGKQ

Anwendungsinformationen

Applikationshinweise: WB: 1.25 µg/mL, IHC: 4-8 µg/mL
Optimal conditions should be determined by the investigator.

Kommentare:

Ankyrin 1 Blocking Peptide, (ABIN5612074), is also available for use as a blocking control in assays to test for specificity of this Ankyrin 1 antibody

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Lyophilized powder. Add distilled water for a 1 mg/mL concentration of ANK1 antibody in PBS

Konzentration: Lot specific

Buffer: PBS

Handhabung: Avoid repeated freeze/thaw cycles.
Dilute only prior to immediate use.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 2-8 °C for short periods. For longer periods of storage, store at -20 °C.

Details zu Erythrocyte Ankyrin

Target: Erythrocyte Ankyrin (ANK1) (Ankyrin 1, Erythrocytic (ANK1))

Andere Bezeichnung: Ankyrin 1

Hintergrund: Ankyrins are a family of proteins that are believed to link the integral membrane proteins to the underlying spectrin-actin cytoskeleton and play key roles in activities such as cell motility, activation, proliferation, contact and the maintenance of specialized membrane domains. Ankyrin 1, the prototype of this family, was first discovered in the erythrocytes, but since has also been found in brain and muscles. Mutations in erythrocytic ankyrin 1 have been associated in approximately half of all patients with hereditary spherocytosis. Complex patterns of alternative splicing in the regulatory domain, giving rise to different isoforms of ankyrin 1 have been described, however, the precise functions of the various isoforms are not known.

Molekulargewicht: 17 kDa (MW of target protein)

Pathways: Synaptic Membrane