BUB1B Antikörper

Produktnummer ABIN6298121

Der Kaninchen Polyklonal Anti-BUB1B-Antikörper wurde für validiert. Er ist geeignet, BUB1B in Proben von Human und Maus zu detektieren.

Kurzübersicht für BUB1B Antikörper (ABIN6298121)

Target: BUB1B (Budding Uninhibited By Benzimidazoles 1 Homolog beta (Yeast) (BUB1B))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BUB1B Antikörper ist unkonjugiert

Applikation: Bitte anfragen

Produktdetails anti-BUB1B Antikörper

Verwendungszweck: Rabbit Anti-BUB1B Antibody,

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: 2-8°C (short-term), -20°C (long-term)

Details zu BUB1B

Target: BUB1B (Budding Uninhibited By Benzimidazoles 1 Homolog beta (Yeast) (BUB1B))

Andere Bezeichnung: BUB1B

Hintergrund:

Target Description: Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression.

Gene Symbol: BUB1B

Gen-ID: 701

UniProt: O60566