USP5 Antikörper
Kurzübersicht für USP5 Antikörper (ABIN6297889)
Target
Alle USP5 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Verwendungszweck
- Mouse Anti-USP5 Antibody
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Immunogen
- This USP5 antibody is generated from a mouse immunized with a recombination protein from the human region of human USP5.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Lagerung
- 4 °C,-20 °C
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Informationen zur Lagerung
- 2-8°C (short-term), -20°C (long-term)
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- USP5 (Ubiquitin Specific Peptidase 5 (USP5))
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Andere Bezeichnung
- USP5
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Hintergrund
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Target Description: Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. Involved in unanchored 'Lys-48'-linked polyubiquitin disassembly. Binds linear and 'Lys- 63'-linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an increase in p53/TP53 transcriptional activity because the unanchored polyubiquitin that accumulates is able to compete with ubiquitinated p53/TP53 but not with MDM2 for proteasomal recognition.
Gene Symbol: USP5
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Gen-ID
- 8078
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UniProt
- P45974
Target
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