KRT17 Antikörper
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- Target Alle KRT17 Antikörper anzeigen
- KRT17 (Keratin 17 (KRT17))
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Reaktivität
- Human, Ratte, Rind (Kuh), Schwein, Ziege
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser KRT17 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS)
- Verwendungszweck
- Mouse anti-Human/Rat/Cow/Goat/Pig Cytokeratin 17 Antibody [Sodium Azide Free]
- Spezifität
- Cytoplasmic
- Aufreinigung
- The cytoskeletal fraction of rat colon epithelium was used as the immunogen for this Cytokeratin 17 antibody.
- Immunogen
- The cytoskeletal fraction of rat colon epithelium was used as the immunogen for this Cytokeratin 17 antibody.
- Top Product
- Discover our top product KRT17 Primärantikörper
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- Applikationshinweise
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FACS: 0.5-1 μg/million cells
IF: 1-2 μg/mL
WB: 0.5-1 μg/mL
IHC (FFPE): 0.5-1 μg/mL for 30 min at RT (1)
Prediluted format: incubate for 30 min at RT (2) - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Buffer
- In 1X PBS ( pH 7.4), BSA free, sodium azide free
- Konservierungsmittel
- Azide free
- Lagerung
- 4 °C,-20 °C
- Informationen zur Lagerung
- 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.
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- Target
- KRT17 (Keratin 17 (KRT17))
- Andere Bezeichnung
- Keratin, type I cytoskeletal 17 (KRT17 Produkte)
- Synonyme
- K17 antikoerper, Krt1-17 antikoerper, PC antikoerper, PC2 antikoerper, PCHC1 antikoerper, Ka17 antikoerper, KRT17 antikoerper, krt16 antikoerper, si:dkeyp-113d7.7 antikoerper, KRT14 antikoerper, keratin 17 antikoerper, keratin 17 L homeolog antikoerper, keratin 17, type I antikoerper, keratin, type I cytoskeletal 17 antikoerper, Krt17 antikoerper, KRT17 antikoerper, krt17 antikoerper, krt17.L antikoerper, LOC100737113 antikoerper, LOC102177275 antikoerper
- Hintergrund
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Target Description: Cytokeratin 17 (CK17, Keratin 17) is a member of the Cytokeratin subfamily of intermediate filament proteins (IFP 's). It is unique in that it is normally expressed in the basal cells of complex epithelia but not in stratified or simple epithelia. Cytokeratin 17 is expressed in the nail bed, hair follicle, sebaceous glands and other epidermal appendages. Antibody to cytokeratin 17 is an excellent tool to distinguish myoepithelial cells from luminal epithelium of various glands such as mammary, sweat and salivary. It is expressed in epithelial cells of various origins, such as bronchial epithelial cells and skin appendages. It may be considered as ""epithelial stem cell "" marker because cytokeratin 17 antibody marks basal cell differentiation. Cytokeratin 17 can be useful when included in a panel of antibodies against TTF-1, napsin A, CK5&6, p63, and SOX-2 for diagnostic differentiation between lung adenocarcinoma (LADC) and lung squamous cell carcinoma (SCLC), especially for poorly-differentiated lung carcinoma. Cytokeratin 17 is expressed in SCLC much higher than in LADC. In breast carcinomas, approximately 20 % of patients show no expression of ER, PR and Her2, which are defined as triple negative tumor. Eighty-five percent of the triple negative breast carcinomas immunoreact with basal cytokeratins including cytokeratin 17 antibody. Also important is that cases of triple negative breast carcinoma with expression of keratin 17 show an aggressive clinical course. The histologic differentiation of ampullary cancer, intestinal vs. pancreatobiliary, is very important for treatment. Usually antibody to cytokeratin 17 and MUC1 immunoreactivity represents pancreatobiliary subtype whereas antibody to MUC2 and CDX2 positivity defines intestinal subtype.
Gene Symbol: KRT17
- Gen-ID
- 3872
- UniProt
- Q04695
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