Keratin 10 Antikörper

Produktnummer ABIN6297642

Dieses Anti-Keratin 10-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von Keratin 10 in IHC, FACS und IF. Geeignet für Human und Maus.

Kurzübersicht für Keratin 10 Antikörper (ABIN6297642)

Target: Keratin 10 (KRT10)

Reaktivität: Human, Maus

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Keratin 10 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunofluorescence (IF)

Produktdetails anti-Keratin 10 Antikörper

Verwendungszweck: Mouse anti-Human/Mouse Cytokeratin 10 Antibody [Sodium Azide Free]

Spezifität: Cytoplasmic

Aufreinigung: Skin extract from a human psoriasis patient was used as the immunogen for this Cytokeratin 10 antibody.

Immunogen: Skin extract from a human psoriasis patient was used as the immunogen for this Cytokeratin 10 antibody.

Anwendungsinformationen

Applikationshinweise: FACS: 0.5-1 μg/million cells
IF: 0.5-1 μg/mL
IHC (FFPE): 0.5-1 μg/mL for 30 minutes at RT (1)
Prediluted format: incubate for 30 min at RT (2)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: In 1X PBS ( pH 7.4), BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Details zu Keratin 10

Target: Keratin 10 (KRT10)

Andere Bezeichnung: Keratin, type I cytoskeletal 10

Hintergrund:

Target Description: This antibody recognizes a protein of 56.5 kDa, identified as cytokeratin 10 (CK10). cytokeratin 10 is expressed in all suprabasal layers of the epidermis. In the epidermis, expression of cytokeratin 10 strictly parallels the extent of differentiation, it is absent in the basal layer, appears in the first suprabasal layers and increases in concentration towards the granular layer. However, cytokeratin 10 is rarely detected in early stages of vulvar squamous carcinomas (tumors less than 2 cm, clinical stage I) regardless of the tumor grade. In larger and more advanced tumors (greater than 2 cm, clinical stages II and III), cytokeratin 10 is detected very frequently. Expression of cytokeratin 10 is related to maturation of malignant keratinocytes, being preferentially detected in more-differentiated parts.

Gene Symbol: KRT10///KPP

Gen-ID: 3858

UniProt: P13645