p63 Antikörper

Produktnummer ABIN6297602

Der Kaninchen Polyklonal Anti-p63-Antikörper wurde für IHC, IF und FACS validiert. Er ist geeignet, p63 in Proben von Human zu detektieren.

Kurzübersicht für p63 Antikörper (ABIN6297602)

Target: p63 (TP63) (Tumor Protein P63 (TP63))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser p63 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS)

Produktdetails anti-p63 Antikörper

Verwendungszweck: Rabbit anti-Human p63 Antibody / Tumor protein 63 [Sodium Azide Free]

Spezifität: Nuclear

Aufreinigung: Recombinant partial human p53 protein was used as the immunogen for this p63 antibody.

Immunogen: Recombinant partial human p53 protein was used as the immunogen for this p63 antibody.

Anwendungsinformationen

Applikationshinweise: Flow Cytometry: 0.5-1 μg/million cells in 0.1ml
Immunofluorescence: 1-2 μg/mL
Immunohistochemistry (FFPE): 1-2 μg/mL for 30 minutes at RT

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: In 1X PBS, BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Details zu p63

Target: p63 (TP63) (Tumor Protein P63 (TP63))

Andere Bezeichnung: Tumor protein 63

Hintergrund:

Target Description: p63 is a homolog of the tumor suppressor p53. It is identified in basal cells in the epithelial layers of a variety of tissues, including epidermis, cervix, urothelium, breast and prostate. p63 was detected in nuclei of the basal epithelium in normal prostate glands, however, it was not expressed in malignant tumors of the prostate. As a result, p63 has been reported as a useful marker for differentiating benign from malignant lesions in the prostate, particularly when used in combination with markers of high molecular weight cytokeratins and the prostate-specific marker AMACR (P504S). p63 has also been shown to be a sensitive marker for lung squamous cell carcinomas (SqCC), with a sensitivity of ~90 % . Specificity for lung SqCC, vs. lung adenocarcinoma (LADC), is approximately 80 %. In breast tissue, p63 has been identified in myoepithelial cells of normal ducts.

Gene Symbol: TP63///KET///P63///P73H///P73L///TP73L

Gen-ID: 8626

UniProt: Q9H3D4