TSH receptor Antikörper

Produktnummer ABIN6297584

Der Maus Monoklonal Anti-TSH receptor-Antikörper wurde für IHC, FACS und IF validiert. Er ist geeignet, TSH receptor in Proben von Human zu detektieren.

Kurzübersicht für TSH receptor Antikörper (ABIN6297584)

Target: TSH receptor (TSHR) (Thyroid Stimulating Hormone Receptor (TSHR))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser TSH receptor Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunofluorescence (IF)

Produktdetails anti-TSH receptor Antikörper

Verwendungszweck: Mouse anti-Human Thyroid Stimulating Hormone Receptor / TSHR Antibody (beta chain) [Sodium Azide Free]

Spezifität: Cytoplasmic, cell surface

Aufreinigung: Recombinant human TSHR beta chain protein was used as the immunogen for this TSH Receptor antibody.

Immunogen: Recombinant human TSHR beta chain protein was used as the immunogen for this TSH Receptor antibody.

Anwendungsinformationen

Applikationshinweise: FACS: 0.5-1 μg/10^6 cells in 0.1ml
IF: 1-2 μg/mL
IHC (FFPE): 1-2 μg/mL for 30 min at RT

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: In 1X PBS, BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Details zu TSH receptor

Target: TSH receptor (TSHR) (Thyroid Stimulating Hormone Receptor (TSHR))

Andere Bezeichnung: Thyrotropin receptor

Hintergrund:

Target Description: Thyroid-stimulating hormone (TSH, also known as thyrotropin) is a glycoprotein involved in the control of thyroid structure and metabolism, which stimulates the release of the thyroid hormones. TSH is regulated by thyroid hormone (T3) and various retinoid compounds. TSH binds to the thyroid-stimulating hormone receptor (TSHR), which is cleaved into two subunits, A and B, and plays a major role in regulating thyroid function. The third cytoplasmic loop of TSHR has been identified as critical for its role in regulating inositol phosphate and cAMP formation. In Graves disease, an autoimmune disorder, TSHR is activated by autoantibodies, which may be stimulated by the cleavage of the A and B subunits.

Gene Symbol: TSHR///LGR3

Gen-ID: 7253

UniProt: P16473

Pathways: Thyroid Hormone Synthesis