TYMS Antikörper

Produktnummer ABIN6297576

Dieses Anti-TYMS-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von TYMS in IHC. Geeignet für Human.

Kurzübersicht für TYMS Antikörper (ABIN6297576)

Target: TYMS (Thymidylate Synthetase (TYMS))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser TYMS Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Produktdetails anti-TYMS Antikörper

Verwendungszweck: Mouse anti-Human Thymidylate Synthase Antibody [IHC only]

Spezifität: Cytoplasmic

Aufreinigung: Recombinant human Thymidylate synthase was used as the immunogen for this antibody.

Immunogen: Recombinant human Thymidylate synthase was used as the immunogen for this antibody.

Anwendungsinformationen

Applikationshinweise: Prediluted format : incubate for 30 min at RT (2)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Prediluted in 1X PBS ( pH 7.4) with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide, For IHC use only

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Details zu TYMS

Target: TYMS (Thymidylate Synthetase (TYMS))

Andere Bezeichnung: Thymidylate synthase

Hintergrund:

Target Description: This antibody is specific for a protein of 36 kDa, identified as Thymidylate Synthase (TS). Thymidylate synthase converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. Thymidylate synthase is also a critical target for the fluoropyrimidines, an important group of anti-neoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates thymidylate synthase by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of thymidylate synthase protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.

Gene Symbol: TYMS///TS///OK///SW-cl.29

Gen-ID: 7298

UniProt: P04818

Pathways: Mitotic G1-G1/S Phases