ALPL Antikörper

Produktnummer ABIN6297134

Der Maus Monoklonal Anti-ALPL-Antikörper wurde für IHC, FACS und IF validiert. Er ist geeignet, ALPL in Proben von Human und Rind (Kuh) zu detektieren.

Kurzübersicht für ALPL Antikörper (ABIN6297134)

Target: ALPL (Alkaline Phosphatase, Liver/bone/kidney (ALPL))

Reaktivität: Human, Rind (Kuh)

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser ALPL Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunofluorescence (IF)

Produktdetails anti-ALPL Antikörper

Verwendungszweck: Mouse anti-Human/Cow Alkaline Phosphatase Antibody (tissue-nonspecific) [Sodium Azide Free]

Spezifität: Cell surface, cytoplasmic, secreted

Aufreinigung: Recombinant human ALPL protein was used as the immunogen for the Alkaline Phosphatase antibody.

Immunogen: Recombinant human ALPL protein was used as the immunogen for the Alkaline Phosphatase antibody.

Anwendungsinformationen

Applikationshinweise: Flow Cytometry: 0.5-1 μg/million cells in 0.1ml
Immunofluorescence: 0.5-1 μg/mL
Immunohistochemistry (FFPE): 1-2 μg/mL for 30 min at RT
Prediluted format: incubate for 30 min at RT (1)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: In 1X PBS, BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Details zu ALPL

Target: ALPL (Alkaline Phosphatase, Liver/bone/kidney (ALPL))

Andere Bezeichnung: Alkaline phosphatase, tissue-nonspecific isozyme

Hintergrund:

Target Description: There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization, however, mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to hypo-phosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms. Alternatively spliced transcript variants, which encode the same protein, have been identified for this gene.

Gene Symbol: ALPL

Gen-ID: 249

UniProt: P05186