Transgelin Antikörper

Produktnummer ABIN6297094

Dieses Maus Monoklonal-Antikörper erkennt spezifisch Transgelin in IHC, FACS und IF. Er zeigt eine Reaktivität gegenüber Human, Maus, Kaninchen, Rind (Kuh) und Schwein.

Kurzübersicht für Transgelin Antikörper (ABIN6297094)

Target: Transgelin (TAGLN)

Reaktivität: Human, Maus, Kaninchen, Rind (Kuh), Schwein

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Transgelin Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunofluorescence (IF)

Produktdetails anti-Transgelin Antikörper

Verwendungszweck: Mouse anti-Human/Cow/Pig/Rabbit/Mouse SM22 alpha Antibody [Sodium Azide Free]

Spezifität: Cytoplasmic

Aufreinigung: Recombinant full-length human protein was used as the immunogen for the SM22 antibody.

Immunogen: Recombinant full-length human protein was used as the immunogen for the SM22 antibody.

Anwendungsinformationen

Applikationshinweise: Flow Cytometry: 0.5-1 μg/million cells in 0.1ml
Immunofluorescence: 1-2 μg/mL
Immunohistochemistry (FFPE): 0.5-1 μg/mL for 30 min at RT (1)
Prediluted format: incubate for 30 min at RT (2)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: In 1X PBS, BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Details zu Transgelin

Target: Transgelin (TAGLN)

Andere Bezeichnung: Transgelin

Hintergrund:

Target Description: This mAb recognizes a 22 kDa protein, identified as Transgelin, also designated SM22-alpha. It may cross-react with SM22-beta. Transgelin is expressed abundantly in smooth muscle cells. The human transgelin gene encodes a 201 amino acid protein that contains nuclear factor-binding motifs known to regulate transcription in smooth muscle. During embryogenesis, transgelin is expressed in smooth, cardiac and skeletal muscle, but is restricted during late fetal development and adulthood to all vascular and visceral smooth muscle cells and low levels of expression in heart. Transgelin is down regulated in several transformed cell lines, indicating that a reduction of transgelin expression may be an early indicator of the onset of transformation. Transgelin also binds Actin, causing Actin fibers to gel within minutes of binding. Binding of transgelin to Actin occurs at a ratio of 1:6 Actin monomers.

Gene Symbol: TAGLN///SM22///WS3-10

Gen-ID: 6876

UniProt: Q01995