IGHA1 Antikörper

Produktnummer ABIN6296837

Der Maus Monoklonal anti-IGHA1 Antikörper wird verwendet zum Nachweis von IGHA1 in Proben von Human. Er wurde validiert für IHC, FACS und IF.

Kurzübersicht für IGHA1 Antikörper (ABIN6296837)

Target: IGHA1 (Immunoglobulin Heavy Constant alpha 1 (IGHA1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser IGHA1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunofluorescence (IF)

Produktdetails anti-IGHA1 Antikörper

Verwendungszweck: Mouse anti-Human IgA Antibody [Sodium Azide Free]

Spezifität: Cytoplasm, cell surface and secreted

Aufreinigung: Purified human alpha heavy chain was used as the immunogen for the Anti-IgA antibody.

Immunogen: Purified human alpha heavy chain was used as the immunogen for the Anti-IgA antibody.

Anwendungsinformationen

Applikationshinweise: Flow Cytometry: 1-2 μg/million cells in 0.1ml
Immunofluorescence: 0.5-1 μg/mL 30 min RT
Immunohistochemistry (FFPE): 0.5-1 μg/mL 30 min RT (1)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: In 1X PBS, BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Details zu IGHA1

Target: IGHA1 (Immunoglobulin Heavy Constant alpha 1 (IGHA1))

Andere Bezeichnung: Immunoglobulin heavy constant alpha 1

Hintergrund:

Target Description: This mAb is specific to heavy chain of IgA and shows minimal cross-reaction with heavy chains of other immunoglobulins. It is reactive with all subclasses of Alpha heavy chain. Immunoglobulins are four-chain, Y-shaped, monomeric structures comprised of two identical heavy chains and two identical light chains held together through inter-chain disulfide bonds. The chains form two domains, the Fab (antigen binding) fragment and the Fc (constant) fragment. Immunoglobulin A (IgA) is the main protein of the mucosal immune system. It is generated by B-cells in gut-associated lymphoid tissues. Daily production of IgA exceeds that of any of the other immunoglobulins. IgA exists mainly in dimers but can also exist as polymers or as monomers. Dimers and polymers contain a joining (J) chain that can be bound by the polymeric immunoglobulin receptor (pIgR) for transportation of the molecule to mucosal surfaces. The most common feature of plasmacytomas, and certain non-Hodgkin s lymphomas is the restricted expression of a single heavy chain class. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is clonal and therefore malignant.

Gene Symbol: IGHA1///IGHA2

UniProt: P01876, P01877