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ACTN2 Antikörper (C-Term)

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch ACTN2 in WB und IHC. Er zeigt eine Reaktivität gegenüber Human, Maus, Ratte und Hund und wurde in 1 Publikation erwähnt.
Produktnummer ABIN629641

Kurzübersicht für ACTN2 Antikörper (C-Term) (ABIN629641)

Target

Alle ACTN2 Antikörper anzeigen
ACTN2 (Actinin, alpha 2 (ACTN2))

Reaktivität

  • 110
  • 64
  • 38
  • 8
  • 5
  • 4
  • 4
  • 4
  • 4
  • 4
  • 3
  • 2
  • 2
  • 2
Human, Maus, Ratte, Hund

Wirt

  • 80
  • 62
Kaninchen

Klonalität

  • 75
  • 67
Polyklonal

Konjugat

  • 61
  • 12
  • 6
  • 5
  • 5
  • 5
  • 5
  • 5
  • 5
  • 5
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser ACTN2 Antikörper ist unkonjugiert

Applikation

  • 113
  • 82
  • 50
  • 19
  • 14
  • 13
  • 13
  • 13
  • 11
  • 11
  • 4
  • 3
  • 3
  • 2
  • 1
  • 1
  • 1
Western Blotting (WB), Immunohistochemistry (IHC)
  • Bindungsspezifität

    • 57
    • 15
    • 9
    • 8
    • 6
    • 6
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term

    Spezifität

    Alpha Actinin 2 antibody was raised against the C terminal of ACTN2

    Aufreinigung

    Purified

    Immunogen

    alpha Actinin 2 antibody was raised using the C terminal of ACTN2 corresponding to a region with amino acids VIASFRILASDKPYILAEELRRELPPDQAQYCIKRMPAYSGPGSVPGALD
  • Applikationshinweise

    WB: 1.25 µg/mL, IHC: 4-8 µg/mL
    Optimal conditions should be determined by the investigator.

    Kommentare

    Alpha Actinin 2 Blocking Peptide, (ABIN5612032), is also available for use as a blocking control in assays to test for specificity of this Alpha Actinin 2 antibody

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Lyophilized powder. Add distilled water for a 1 mg/mL concentration of ACTN2 antibody in PBS

    Konzentration

    Lot specific

    Buffer

    PBS

    Handhabung

    Avoid repeated freeze/thaw cycles.
    Dilute only prior to immediate use.

    Lagerung

    4 °C/-20 °C

    Informationen zur Lagerung

    Store at 2-8 °C for short periods. For longer periods of storage, store at -20 °C.
  • Chopra, Kutys, Zhang, Polacheck, Sheng, Luu, Eyckmans, Hinson, Seidman, Seidman, Chen: "Force Generation via β-Cardiac Myosin, Titin, and α-Actinin Drives Cardiac Sarcomere Assembly from Cell-Matrix Adhesions." in: Developmental cell, Vol. 44, Issue 1, pp. 87-96.e5, (2018) (PubMed).

  • Target

    ACTN2 (Actinin, alpha 2 (ACTN2))

    Andere Bezeichnung

    alpha Actinin 2

    Hintergrund

    The alpha-actinins are a multigene family of four actin-binding proteins related to dystrophin. The two skeletal muscle isoforms of alpha-actinin (ACTN2 and ACTN3) are major structural components of the Z-line involved in anchoring the actin-containing thin filaments. In humans, ACTN2 is expressed in all muscle fibres, while ACTN3 expression is restricted to a subset of type 2 fibres. Murine Actn2 and Actn3 are differentially expressed, spatially and temporally, during embryonic development and, in contrast to humans, alpha-actinin-2 expression does not completely overlap alpha-actinin-3 in postnatal skeletal muscle, suggesting independent function.

    Molekulargewicht

    98 kDa (MW of target protein)

    Pathways

    Cell-Cell Junction Organization, Skeletal Muscle Fiber Development, Negative Regulation of Transporter Activity
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