FOXP3 Antikörper

Produktnummer ABIN6296306

Der Maus Monoklonal Anti-FOXP3-Antikörper wurde für FACS und IF validiert. Er ist geeignet, FOXP3 in Proben von Human, Maus und Affe zu detektieren.

Kurzübersicht für FOXP3 Antikörper (ABIN6296306)

Target: FOXP3 (Forkhead Box P3 (FOXP3))

Reaktivität: Human, Maus, Affe

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser FOXP3 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Immunofluorescence (IF)

Produktdetails anti-FOXP3 Antikörper

Verwendungszweck: Mouse anti-Human/Monkey/Mouse FOXP3 Antibody [Sodium Azide Free]

Spezifität: Predominantly nuclear, some cytoplasmic

Aufreinigung: Full-length His-tagged mouse FOXP3 protein was used as the immunogen for this FOXP3 antibody.

Immunogen: Full-length His-tagged mouse FOXP3 protein was used as the immunogen for this FOXP3 antibody.

Anwendungsinformationen

Applikationshinweise: Flow Cytometry: 0.5-1 μg/million cells in 0.1ml
Immunofluorescence (0.5-1 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: In 1X PBS, BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Details zu FOXP3

Target: FOXP3 (Forkhead Box P3 (FOXP3))

Andere Bezeichnung: Forkhead box protein P3

Hintergrund:

Target Description: Recognizes a protein of 47-55 kDa, which is identified as FOXP3. Its precise epitope is not known, but it has been mapped to the N-terminal portion (amino acids 2-136) of the protein.The FOX family of transcription factors is a large group of proteins that share a common DNA binding domain termed a winged-helix or forkhead domain. During early development, FOXP1 and FOXP2 are expressed abundantly in the lung, with lower levels of expression in neural, intestinal and cardiovascular tissues, where they act as transcription repressors. FOXP1 is widely expressed in adult tissues, while neoplastic cells often exhibit a dramatic change in expression level or localization of FOXP1. Mutations in FOXP3 gene cause IPEX, a fatal, X-linked inherited disorder characterized by immune dysregulation. The FOXP3 protein is essential for normal immune homeostasis. Specifically, FOXP3 represses transcription through a DNA binding forkhead domain, thereby regulating T cell activation.

Gene Symbol: FOXP3///IPEX///JM2

Gen-ID: 50943

UniProt: Q9BZS1

Pathways: Chromatin Binding, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Activated T Cell Proliferation