RNMT Antikörper

Produktnummer ABIN6296035

Dieses Maus Monoklonal-Antikörper erkennt spezifisch RNMT in IHC. Er zeigt eine Reaktivität gegenüber Human, Ratte, Rind (Kuh) und Hund.

Kurzübersicht für RNMT Antikörper (ABIN6296035)

Target: RNMT (RNA Guanine-7 Methyltransferase (RNMT))

Reaktivität: Human, Ratte, Rind (Kuh), Hund

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser RNMT Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Produktdetails anti-RNMT Antikörper

Verwendungszweck: Mouse anti-Human/Cow/Dog/Rat TAG-72 Antibody Cocktail [IHC only]

Spezifität: Cytoplasmic and cell surface

Aufreinigung: A membrane-enriched fraction of a human breast carcinoma liver metastasis (B72.3) and purified TAG-72 protein (CC49) were used as the immunogens for this TAG-72 antibody cocktail.

Immunogen: A membrane-enriched fraction of a human breast carcinoma liver metastasis (B72.3) and purified TAG-72 protein (CC49) were used as the immunogens for this TAG-72 antibody cocktail.

Anwendungsinformationen

Applikationshinweise: Prediluted format : incubate for 30 min at RT (2)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Prediluted in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide, For IHC use only

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Details zu RNMT

Target: RNMT (RNA Guanine-7 Methyltransferase (RNMT))

Andere Bezeichnung: mRNA cap guanine-N7 methyltransferase  

Hintergrund:

Target Description: Recognizes an oncofetal antigen of 220 kDa, identified as a tumor-associated glycoprotein (TAG-72) with properties of a mucin. This mAb defines the mucin-carried sialylated-Tn epitope. TAG-72 is usually expressed by adenocarcinomas, but is negative in mesotheliomas. Studies have reported that this antibody has 80 % sensitivity and 93 % specificity for pulmonary adenocarcinoma. Therefore, TAG-72 is a useful marker to distinguish between mesothelioma and adenocarcinoma. However, false positive reactions can occur so results must be interpreted with the utmost caution. This antibody may be useful in the differentiation of non-small cell carcinomas from small cell carcinomas of the lung. The combined use of anti-TAG-72 and anti-GCDFP-15 is valuable in the diagnosis of apocrine carcinoma.

Gene Symbol: tag-72  C25A1.3

Gen-ID: 182875

UniProt: Q9XVS1